便秘与孤立的REM睡眠行为障碍中的加速认知和运动衰退有关
Kyung Ah Woo1, Seoyeon Kim1, Hyunwoo Nam1
1Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea.
Parkinsonism & related disorders
|July 31, 2023
概括
孤立REM睡眠行为障碍 (iRBD) 患者的便秘与较快的运动和认知能力下降有关. 这一发现强调了便秘是帕金森病进展的潜在早期指标.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 便秘是帕金森病 (PD) 认知衰退的已知预测因素.
- 便秘与前性PD阶段 (iRBD) 的运动/认知轨迹之间的关联尚未得到充分理解.
研究的目的:
- 为了研究便秘和运动和认知症状的进展之间的关系,在与孤立的REM睡眠行为障碍 (iRBD) 的个体.
主要方法:
- 对iRBD受试者进行了一项纵向前性队列研究.
- 参与者进行了运动功能 (MDS-UPDRS-III) 和认知 (MMSE) 的反复评估.
- 概括估计方程 (GEE) 比较了iRBD受试者在基线有或没有便秘时的症状轨迹.
主要成果:
- 29名患有便秘的iRBD受试者和24名没有便秘的受试者被跟踪超过4年.
- 便秘组的MDS-UPDRS-III和MMSE分数下降速度明显更快.
- 在便秘组中,MDS-UPDRS-III的估计年进展率为+1.242,MMSE的估计年进展率为-0.713.
结论:
- 在iRBD中,便秘与加速的运动症状进展有关.
- 在iRBD中,便秘与认知功能下降的速度更快有关.
- 这表明便秘可能是PD进展的早期非运动标志物.
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