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针对大脑电路的治疗方法的未来

Shan H Siddiqi^1,2, Sanaz Khosravani^3,4, John D Rolston^3,5

¹Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA. shsiddiqi@bwh.harvard.edu.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

|July 31, 2023

概括

这项研究提出了一个三阶段框架,用于选择TMS和DBS等神经调节疗法的大脑电路目标. 这种方法旨在通过优化目标识别和刺激方法来改善神经精神疾病的治疗.

科学领域:

神经科学是一个神经科学.
神经调节是一种神经调节.
脑电路治疗学脑电路治疗学

背景情况:

脑刺激技术,如跨磁刺激 (TMS),深度脑刺激 (DBS) 和聚焦超声波 (FUS) 越来越多地用于神经精神疾病.
有效的治疗依赖于精确准特定的大脑电路.
目前用于目标识别和调制的方法需要一个结构化的框架.

研究的目的:

为神经调节疗法提出一个全面的三阶段框架,用于识别和调节神经调节疗法的脑电路目标.
引导选择适当的刺激目标和治疗神经精神疾病的方法.

主要方法:

第一个阶段:使用相关神经成像,回顾性优化和病变定位来识别目标.
第二阶段:通过个性化神经成像,生理监测和状态参与 (药物/心理) 来优化目标.
第三阶段:选择模式,考虑不同脑刺激技术的优点和缺点.

主要成果:

拟议的框架整合了多种目标识别和优化方法.
它提供了一种系统的方法来选择最合适的刺激方式或组合.
初步文献支持框架的各个组成部分,表明其潜在的临床实用性.

结论:

该框架提供了一种结构化的方法来推进大脑电路疗法.
需要进一步的研究来解决未解答的问题,并完善框架.
这项工作为神经调节的研究和临床应用提供了未来增长的机会.

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