患者报告的三项工具用于在资源有限的环境中追溯遵守:可靠性,有效性和潜在的实用性
Seth C Kalichman1, Ellen Banas2,3, Bruno Shkembi2
1Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, 406 Babbidge Road, Storrs, CT, 06269, USA. seth.k@uconn.edu.
Journal of behavioral medicine
|July 31, 2023
概括
三项追溯依从性仪器 (IRA) 可靠地测量资源有限的环境中艾滋病毒患者的药物依从性. 这种经过验证的工具支持其在临床护理和研究中的使用,以改善患者的治疗结果.
科学领域:
- 临床药理学 临床药理学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 患者报告的结果措施对于监测临床实践中的药物坚持至关重要.
- 现有工具在可靠性和有效性方面面临挑战,需要强大的评估工具.
- 三项追溯合规工具 (IRA) 在监测合规方面表现有前途.
研究的目的:
- 在资源有限的环境中评估IRA的可靠性和有效性.
- 在南非开普敦接受抗逆转录病毒治疗 (ART) 的患者中评估IRA的表现.
主要方法:
- 接受ART的1022名患者 (794名女性,228名男性) 在入学,1周和1个月的随访期间完成了IRA.
- 客观的遵守措施包括未宣布的药片计数和艾滋病毒病毒载量测试.
- 分析了数据的内部一致性,时间稳定性和对客观指标的有效性.
主要成果:
- 爱尔兰国民投资基金表现出良好的内部一致性和时间稳定性.
- 与药丸计数,坚持相关系数和艾滋病毒病毒载量相比,IRA得分显示出显著的有效性.
- 接收器操作曲线分析表明在识别粘附水平方面具有中等准确性.
结论:
- 在资源有限的环境中,IRA是一种可靠和有效的工具,用于评估药物坚持.
- 研究结果支持IRA在HIV管理的研究和临床环境中使用.
- 该IRA提供了一种可行的方法来监测遵守,潜在地改善患者的结果.
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