相关实验视频

Updated: Jul 20, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

基于深度学习的蛋白质-蛋白质相互作用分析,用于预测SARS-CoV-2的感染性和变体演变

Guangyu Wang¹, Xiaohong Liu^2,3, Kai Wang⁴

¹State Key Laboratory of Networking and Switching Technology, Beijing University of Posts and Telecommunications, Beijing, China. guangyu.wang24@gmail.com.

Nature medicine

|July 31, 2023

概括

一个AI框架UniBind可以预测病毒变异如何影响蛋白质结合. 该工具有助于预测新的SARS-CoV-2变种,并了解早期预警系统的病毒演变.

科学领域:

计算生物学计算生物学
结构生物学结构生物学
人工智能的人工智能

背景情况:

蛋白质与蛋白质的相互作用对于宿主-病原体动态和病毒进化至关重要.
了解病毒变异如何改变这些相互作用是预测病原菌株的出现的关键,比如新的SARS-CoV-2变异.

研究的目的:

开发和验证基于AI的框架UniBind,用于预测蛋白质变体对结合亲和关系的影响.
评估UniBind在预测SARS-CoV-2变种对宿主和抗体相互作用的影响方面的能力.

主要方法:

UniBind以残留和原子水平的图形表示蛋白质,集成3D结构和结合亲和数据.
该框架采用多任务学习来实现异构的生物数据集成.
对基准数据集和实验验证进行了系统测试.

主要成果:

UniBind准确且可扩展地预测了SARS-CoV-2尖端蛋白变体对ACE2受体和中和抗体的结合 afinities 的影响.
跨物种分析表明,UniBind在预测宿主易感性和病毒进化趋势方面具有实用性.

结论:

UniBind提供了一种强大的in silico方法,用于预测病毒变异对蛋白质-蛋白质相互作用的影响.
该框架可以作为新出现的SARS-CoV-2变种的早期预警系统,并推进一般蛋白质-蛋白质相互作用研究.

更多相关视频

An Integrated Approach for Microprotein Identification and Sequence Analysis

An Integrated Approach for Microprotein Identification and Sequence Analysis

Published on: July 12, 2022

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Author Spotlight: A Pseudotype Virus System for Assessing Omicron Subvariants and Neutralizing Antibodies in SARS-CoV-2 Research

Published on: September 8, 2023

相关概念视频

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein-Protein Interfaces

Protein-Protein Interfaces