冠状动脉血管功能障碍与患有外周动脉疾病的患者死亡风险增加有关
Poghni A Peri-Okonny1,2, Krishna K Patel3, R Angel Garcia4,5
1Department of Cardiology, University of Missouri-Kansas City, Kansas City, MO, USA. apoghni@gmail.com.
概括
冠状动脉血管功能障碍,以心肌血流量储量 (MBFR) < 2 表示,在患有外周动脉疾病 (PAD) 的患者中很普遍. 这种功能障碍显著增加了PAD患者因任何原因死亡的风险,突出了这些疾病之间的关键联系.
科学领域:
- 心脏病学 心脏病学
- 血管医学 血管医学
- 诊断成像 诊断成像 诊断成像
背景情况:
- 周围动脉疾病 (PAD) 和冠状动脉血管功能障碍是心脏代谢疾病中常见的并发症.
- 同时PAD和冠状动脉血管功能障碍的患病率和预后意义仍未得到充分研究.
研究的目的:
- 调查PAD患者冠状动脉血管功能障碍的患病率.
- 为了确定PAD和冠状动脉血管功能障碍对死亡率的预后影响.
主要方法:
- 对连续接受PET MPI的患者进行分析,以评估冠状动脉血管功能障碍 (MBFR < 2).
- 利用考克斯回归来评估减少MBFR与PAD患者死亡率的关联.
- 研究了PAD和MBFR<2对所有死因的综合影响.
主要成果:
- 分析了13,940名患者;14%的人患有PAD,56%的人患有MBFR<2,10%的人患有两者.
- 在69.5%的患者中观察到降低的MBFR,并且与PAD患者死亡风险增加1.69倍有关.
- 与没有这两种情况的患者相比,患有PAD和降低MBFR的患者死亡风险增加了2.30倍.
结论:
- 冠状动脉血管功能障碍在被诊断为PAD的患者中非常普遍.
- 在PAD患者中,冠状动脉血管功能障碍的存在与死亡风险的增加显著相关.
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