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Updated: Jul 20, 2025

Characterizing Individual Protein Aggregates by Infrared Nanospectroscopy and Atomic Force Microscopy
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建立一个生物AFM来研究神经退行性疾病中的蛋白质错折

Dionysios Cheirdaris1, Marios G Krokidis1, Marianne Kasti1

  • 1Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, Corfu, Greece.

Advances in experimental medicine and biology
|July 31, 2023
PubMed
概括

本研究详细介绍了基于原子力显微镜的单分子力光谱 (AFM-SMFS) 用于分析神经退行性疾病中的蛋白质错折. 它捕捉了分子解绑力,揭示了疾病进展和蛋白质动态的洞察力.

关键词:
原子力显微镜的原子力显微镜.强力-距离曲线的曲线.检测蛋白质的探测方法单分子力光谱学 单分子力光谱学

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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