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在中使用概率扩散轨迹学方法进行福尼克斯交叉后的结构连接变化.

Vassilis Pelekanos1, Elsie Premereur2, Anna S Mitchell3,4

  • 1School of Medicine, University of Nottingham, Nottingham, UK. v.pelekanos@nottingham.ac.uk.

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|July 31, 2023
PubMed
概括
此摘要是机器生成的。

的切割改变了大脑连接,特别是在前丘脑,CA3和ACC之间. 这些变化揭示了潜在的间接途径,支持大脑损伤后的记忆.

关键词:
在前带带上,前带带上.在前丘脑前部的前丘脑.扩散权重的MRI测试结果福尼克斯 (Fornix) 是一个在海马体内,海马体概率学曲谱学 概率学曲谱学 概率学曲谱学脑后大脑皮层 (Retrosplenial cortex) 是一个脑后大脑皮层.

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科学领域:

  • 神经科学是一个神经科学.
  • 神经成像是一种神经成像.
  • 系统神经科学 系统神经科学

背景情况:

  • 体是边缘系统中一个关键的白质道,对学习和记忆至关重要.
  • 了解福尼克斯对大脑网络的损伤影响对于记忆研究至关重要.

研究的目的:

  • 在非人类灵长类动物 (NHPs) 中,在骨切割后,研究皮层和皮下区域的结构连接性变化.
  • 识别潜在的间接神经通路,可以在部损伤后补偿记忆功能.

主要方法:

  • 扩散权重核磁共振 (dMRI) 数据是在双边骨切割或假手术前后从子中收集的.
  • 使用概率曲谱来量化预定义的兴趣区域 (ROI) 之间的结构连接性.

主要成果:

  • 与对照组相比,Forix-transected NHPs显示出显著的连接性改变.
  • 观察到前丘脑和前带状皮层 (ACC) 之间以及CA3和ACC之间增加了连接性.
  • 在CA3海马子场和后皮质 (RSC) 之间发现连接性下降.

结论:

  • 福尼克斯切口诱导皮层和皮层下网络连接的实质性变化.
  • 该研究确定了潜在的间接路线,例如涉及ACC的路线,这些路线可能在伤害后维护记忆功能方面发挥作用.