炎症生物标志物与静脉血栓塞栓症之间的关联:系统性审查和元分析
Jiayue Ding1,2, Xuanye Yue3,4, Xiaobing Tian3,4
1Department of Neurology, Tianjin Medical University General Hospital, Tianjin, 300052, China. sjnkzz2@163.com.
Thrombosis journal
|July 31, 2023
概括
炎症生物标志物如hs-CRP和CRP的升高是静脉血栓栓塞 (VTE) 的危险因素. 这些标志物和其他标志物一起,可以表明先前或急性VTE事件,有助于临床评估.
科学领域:
- 医学研究 医学研究
- 生物标志物的分析分析.
- 血管疾病是血管疾病.
背景情况:
- 静脉血栓塞栓症 (VTE) 是一种普遍的血管疾病,影响患者的福祉.
- 现有关于炎症生物标志物和VTE的研究显示了相互矛盾的结果.
- 这一元分析旨在综合现有证据,以便得出更明确的结论.
研究的目的:
- 调查炎症生物标志物与静脉血栓塞栓症 (VTE) 风险之间的关联.
- 为了确定特定的炎症标志物是否可以预测未来的静脉瘤发作.
- 探索炎症生物标志物在识别先前或急性VTE事件中的作用.
主要方法:
- 在多个数据库中进行了全面的文献搜索,截至2023年4月.
- 通过使用统计软件 (Stata和R) 分析了来自25篇选定的文章的数据.
- 分析包括了关于肺栓塞,深静脉血栓和脑静脉血栓的研究,这些研究在PROSPERO (CRD42022321815) 下注册.
主要成果:
- 高敏感性C反应蛋白 (hs-CRP) 和C反应蛋白 (CRP) >3μg/ml的较高水平与未来风险增加有关.
- 单细胞,hs-CRP,CRP和IL-6水平升高可能表明有VTE病史.
- 包括白细胞,中性粒细胞,单细胞,hs-CRP,IL-6,血小板-淋巴细胞比率和中性粒细胞-淋巴细胞比率在VTE急性阶段出现升高.
结论:
- 激活的炎症生物标志物与VTE的风险增加有关.
- 这些生物标志物可以作为临床实践中VTE发生的指标.
- 这些发现支持在VTE风险评估和诊断中使用炎症标志物.
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