在中老年和老年人中,阿迪波金,骨肌功能和骨矿物质密度之间存在潜在的相关性
Wenhao Wang1,2, Xuchao Gu1,2, Ziyi Cao1,3
1Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai, 200040, China.
Lipids in health and disease
|July 31, 2023
概括
炎症与老年人骨肌肉功能和骨矿物质密度 (BMD) 的降低有关. 较高水平的阿迪波金 (LEP,ADIPOQ,RBP4,DPP4) 与较差的肌肉和骨健康有关.
科学领域:
- 老年学是一门学科.
- 生物化学 生物化学
- 整形外科 整形外科 整形外科
背景情况:
- 炎症与骨肌功能和骨矿物质密度 (BMD) 的下降有关.
- 关联炎症,肌肉和骨健康的确切机制尚不清楚.
- 炎症调节剂阿迪波金可能在这些过程中发挥作用.
研究的目的:
- 为了研究adipokines,骨肌功能和中老年人和老年人的BMD之间的相关性.
- 为了确定与肌肉和骨健康相关的潜在阿迪波金标.
主要方法:
- 在中国上海对460名中老年人和老年人 (125人被分析) 进行了横截面研究.
- 测量生物化学指数,身体组成,骨肌功能和BMD.
- 生物信息分析,西部抹杀 (WB) 和与酶相关的免疫吸收试验 (ELISA) 来识别和验证阿迪波金标.
主要成果:
- 较低的骨肌肉质量与较差的握力,较慢的椅子站测试和较低的部/大腿部部BMD相关.
- 肌肉质量较低的个体具有较高的炎症标志物.
- LEP,ADIPOQ,RBP4和DPP4被确定为潜在的阿迪波金标;在肌肉功能下降和BMD的个体中发现了更高的水平.
结论:
- 骨肌功能与BMD正相关,与老年人炎症标志物负相关.
- 较低的骨肌功能和BMD与LEP,ADIPOQ,RBP4和DPP4的表达增加有关.
- 阿迪波金可能与肌肉和骨健康的衰退有关.
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