相关实验视频

Updated: Jul 20, 2025

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

LSD1:在改变瘤微环境和增强免疫检查点治疗方面,一个新兴的面孔

M A A Mamun¹, Yu Zhang¹, Jin-Yuan Zhao¹

¹Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, China, State Key Laboratory of Esophageal Cancer Prevention and Treatment, Key Laboratory of Henan Province for Drug Quality and Evaluation, Institute of Drug Discovery and Development, School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, China.

Journal of biomedical science

|July 31, 2023

概括

氨酸特异性去甲基酶1 (LSD1) 失调促进瘤生长和免疫抑制. 用抑制剂向LSD1,结合免疫检查点阻塞 (ICB),对未来的癌症疗法显示出希望.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

瘤微环境 (TME) 细胞失调促进瘤生长和免疫逃避.
针对酶的表观遗传药物,如氨酸特异性去甲基酶1 (LSD1),是有前途的癌症治疗方法.
LSD1功能障碍与癌症的预后不佳,耐药性和免疫抑制有关.

研究的目的:

审查LSD1在调节TME细胞行为中的作用.
突出LSD1抑制剂与免疫检查点阻塞 (ICB) 结合的治疗潜力.

主要方法:

关于LSD1在TME中的功能研究的文献综述.
对LSD1抑制剂和ICB疗效的现有数据的分析.

主要成果:

LSD1影响TME内的各种细胞类型,影响瘤的进展.
抑制LSD1表明有可能逆转免疫抑制的TME表型.
用LSD1抑制剂和ICB联合治疗可以克服治疗耐药性.

结论:

LSD1是TME中的一个关键的表观遗传调节器.
针对LSD1提供了一种新的策略,以提高ICB的疗效.
进一步研究与ICB结合的LSD1抑制剂对于癌症治疗的发展是有必要的.

关键词:

表观遗传TME调节的规范免疫检查站封锁免疫检查站封锁免疫抑制是一种免疫抑制.一个LSD1一个LSD1 瘤微环境是一个微环境.

更多相关视频

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8+ T Cells During LN Metastasis

Author Spotlight: A Model to Study the Systemic and Local Dynamics of CD8⁺ T Cells During LN Metastasis

Published on: January 26, 2024

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports

Published on: November 28, 2019

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...