运动诱导的虹膜素通过抑制PCOS中的IRE1α-TXNIP/ROS-NLRP3通路来改善毛囊功能障碍
Yajing Weng1, Yaling Zhang2, Daojuan Wang3
1State Key Laboratory of Analytical Chemistry for Life Science & Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University, Nanjing, 210093, China.
Journal of ovarian research
|July 31, 2023
概括
运动和虹素治疗通过减少氧化应激和炎症来改善多囊卵巢综合征 (PCOS). 这项研究表明,运动可以缓解大鼠的PCOS症状,可能是通过虹膜素.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 运动生理学 运动生理学
背景情况:
- 多囊性卵巢综合征 (PCOS) 的特征是高雄性,导致氧化应激和炎症细胞中的炎症激活,导致卵泡发育障碍和不孕症.
- 运动可以调节氧化应激和炎症的降低,从而调节新陈代谢的myokine的irisin,并且在临床试验中显示出缓解PCOS症状的前景.
研究的目的:
- 在大鼠模型中研究运动和虹膜素干预对高雄激素诱导的PCOS的治疗效果.
- 阐明涉及氧化应激,炎症和内质网膜应激的潜在分子机制.
主要方法:
- 雌性斯普拉格 - 达利大鼠被给予脱水氨 (DHEA) 或二氨 (DHT) 来诱导高雄性环境,随后进行了为期八周的运动训练和虹素干预.
- 氧化应激 (ROS),炎症,内分泌网膜应激 (ERS) 和纤维化的主要分子标志物被评估,使用包括西部斑点,qRT-PCR,免疫光和组织学染色等技术.
主要成果:
- 八周的运动显著改善了多囊性卵巢形态,并减少了PCOS大鼠的炎症,氧化应激和纤维化.
- 过高雄激素症通过IRE1α-TXNIP/ROS-NLRP3信号通路加剧了ROS的产生,增加了炎症.
- 虹膜素干预抑制了IRE1α的表达,减轻了卵巢功能障碍和改善了PCOS表型.
结论:
- 运动有效地减轻PCOS表型在老鼠模型中,治疗益处可能由肌分泌物,如素介导.
- 需要内醇的酶1α (IRE1α) 途径被确定为减少氧化应激和炎症,从而改善PCOS中的卵巢纤维化作用的素作用的关键标.
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