预测者和动态在线名谱术后延迟低血症在内透视腺腺瘤内镜外科手术后:一个单中心,回顾性,观察性队列研究与外部验证
Xiangming Cai1,2,3, An Zhang1, Peng Zhao4
1Department of Neurosurgery, Jinling Hospital, Nanjing, China.
Chinese neurosurgical journal
|July 31, 2023
概括
下垂体腺瘤手术后的术后延迟低血 (PDH) 是常见的. 确定了新的预测因素,包括前列血时间和单细胞百分比,从而为早期风险评估提供了有用的诺姆图谱.
科学领域:
- 神经外科 神经外科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 手术后延迟性低血症 (PDH) 是 pituitary adenomas (PAs) 进行内透膜外科手术 (eTSS) 后重新入院的重要原因.
- 确定的PDH风险因素仍然有限,需要一个预测工具.
研究的目的:
- 在PAs的eTSS之后确定PDH的预测因素.
- 开发和验证用于预测PDH的动态在线名谱.
主要方法:
- 对226名接受PASeTSS的患者进行分析,并使用97名患者进行外部验证.
- PDH定义为手术后第3天或之后的血清<137 mmol/L.
- 多变量逻辑回归和名ogram构造.
主要成果:
- 术后1-2天的低血,前血时间 (PT) 和单细胞百分比是PDH的显著预测因素.
- 在内部 (AUC:0.613-0.688) 和外部 (AUC:0.594-0.617) 验证中,名图表显示出良好的区别.
- 诺米图表显示了各种患者子组的良好校准和决策实用性.
结论:
- 手术前的PT和单细胞百分比是PDH的新型预测指标.
- 开发的动态名图是PAS在eTSS后预测PDH的有价值和可概括的工具.
- 早期识别PDH风险可以优化治疗决策和患者的治疗结果.
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