母亲暴露于微量元素,有毒金属和婴儿人体测量和生长轨迹的纵向变化:一个前性队列研究
Xiaochen Zhang1,2, Hongcheng Wei1,2, Quanquan Guan1,2
1State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Environmental science & technology
|August 1, 2023
概括
孕妇在怀孕早期接触到 (V) 和 (Cr),会对婴儿的生长轨迹产生积极的影响. 这突出了早期怀孕作为影响婴儿发育的微量元素暴露的关键窗口.
科学领域:
- 环境健康 环境健康
- 儿科 儿科 儿科
- 毒理学 毒理学 毒理学
背景情况:
- 孕妇在怀孕期间接触微量元素和有毒金属会影响婴儿的生长.
- 了解特定阶段的影响对于早期健康管理至关重要.
- 产前暴露基对婴儿生长轨迹的影响需要进一步研究.
研究的目的:
- 探索母体微量元素和有毒金属暴露对婴儿持续生长的特定阶段的影响.
- 确定孕期暴露的关键窗口,影响婴儿生长轨迹.
- 将母亲的元素暴露与婴儿明显的生长模式联系起来.
主要方法:
- 在中国 (2014-2015年) 919对母婴对进行的前性队列研究.
- 在怀孕早期和晚期测量17种元素的尿液水平.
- 在1,3,6,8和12个月的婴儿的纵向人体测量评估.
- 三步纵向和高维数据分析,以评估暴露对增长的影响.
主要成果:
- 怀孕早期对 (V) 和 (Cr) 的暴露显示出与长度对年龄z分数 (LAZ) 的积极关联.
- 根据LAZ确定了六种不同的婴儿生长轨迹.
- 孕妇暴露于V和Cr,以及怀孕早期的混合微量元素与高稳定生长轨迹的更高几率有关.
结论:
- 怀孕期间母亲的微量元素暴露体与婴儿的动态生长有积极的关联.
- (V) 和 (Cr) 是影响婴儿生长的关键元素.
- 怀孕早期是母亲暴露于微量元素影响婴儿发育的关键时刻.
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