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应用风湿病学教训来更好地了解长期COVID

Don L Goldenberg¹

¹Tufts University School of Medicine, Boston, Massachusetts, and Oregon Health Sciences University, Portland.

Arthritis care & research

|August 1, 2023

概括

长期COVID与纤维肌痛和ME/CFS共享症状,通常没有器官损伤. 长期COVID的研究可能会揭示这些相关慢性疾病的原因和治疗方法.

科学领域:

免疫学免疫学免疫学
神经学神经学
类风湿病学类风湿病学

背景情况:

长期COVID症状通常缺乏器官损伤或异常生物标志物的证据,特别是在轻度SARS-CoV-2感染中.
长期COVID患者的持续症状类似于纤维肌痛 (FM) 和肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 的症状.
关键的重叠症状包括疲劳,炼后的不适,疼痛和睡眠/认知障碍.

研究的目的:

探索长期COVID,FM和ME/CFS之间病理生理学的相似之处.
突出共同研究和治疗策略的潜力.
为了强调根据器官损伤的存在区分长期COVID的重要性.

主要方法:

在长期COVID,FM和ME/CFS中对病理生理路径的比较分析.
审查关于免疫失调和神经系统功能障碍的现有文献.
检查当前的多学科治疗方法.

主要成果:

类似的途径包括宿主-微生物相互作用,免疫失调和神经系统功能障碍,没有系统性自身免疫.
用于FM和ME/CFS的多学科管理策略正在应用于长期COVID.
长期COVID患者参与研究为FM和ME/CFS社区提供了潜在的好处.

结论:

长期COVID,FM和ME/CFS共享潜在的病理生理机制,特别是在没有器官损伤的情况下.
长期COVID研究的进展可以显著提高对FM和ME/CFS的理解和治疗.
风湿病学家在长期COVID研究和患者护理中发挥着至关重要的作用.

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