具有囊细胞特征的侵袭性叶状癌的临床病理学和免疫类型分类
Zachary Coty-Fattal1, Shubhanjali Minhas2, Monica Butcher1
1Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
International journal of surgical pathology
|August 1, 2023
概括
囊细胞状叶状乳腺癌是一种罕见的侵袭性叶状叶状乳腺癌亚型,表现出多种不同的免疫组织化学特征. 大多数患者经历了优秀的结果,这表明这种乳腺癌变体的一般性质是惰的.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 是一个遗传学.
背景情况:
- 阴囊细胞状球状乳腺癌是一种罕见的侵袭性球状乳腺癌亚型.
- 它的特点是平淡的核,颗粒状细胞质,通常是三阴性,雄激素受体 (AR) 阳性状态.
- 理论上代表了非分的分化,有事证据表明有利的结果.
研究的目的:
- 为了研究胰岛细胞球状乳腺癌的临床病理特征和结果.
- 分析这些瘤的免疫组织化学概况.
- 评估患者队列中的生存率和转移性疾病.
主要方法:
- 在2008年至2021年期间诊断的12名患者的回顾性审查.
- 对血素和欧片以及免疫组织化学染料 (ER,PR,HER2,AR,EGFR,KRT5/6) 的分析.
- 评估患者的结果,包括生存率和转移.
主要成果:
- 12名符合条件的患者被确定具有囊细胞特征.
- 免疫类型不同: 4/12 三重阴性/AR阳性, 7/12 光线B, 1/12 HER2丰富.
- 没有与疾病相关的死亡; 2/12 呈现远程转移.
结论:
- 囊细胞状球状乳腺癌是一种具有阿波克林特征的形态变体.
- 呈现出可变的免疫组织化学特征和临床行为.
- 进一步分类可能有助于区分惰和攻击性病例.
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