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快速输注率与标准输注率氧沙的安全结果
Thao Huynh1, Nick Crozier2, Lisa Anselmo1
1University of New Mexico Hospital, Albuquerque, NM, USA.
概括
在癌症治疗中快速服用牛利,没有增加过敏反应,但导致了更多的外围神经病变. 更快的输液速度可能不会超过神经损伤的风险增加.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 临床癌症研究 临床癌症研究
背景情况:
- 国家综合癌症网络的指导方针表明,对于胃肠道癌症,可以接受快速输注氧沙 (85分钟).
- 标准的oxaliplatin输注时间为120分钟.
研究的目的:
- 为了评估与标准输注速率相比,快速施用牛利的安全结果.
- 评估与更快的氧沙注入相关的过敏反应和不良药物事件.
主要方法:
- 一项回顾性队列研究,包括178名成年患者在FOLFOX,FOLFOXIRI或FOLRINOX疗法中接受氧化.
- 从2018年1月到2021年6月,通过图表审查收集的数据.
- 主要结局:过敏反应 (HSR) 和治疗修改;次要结局:外围神经病变 (PN),骨髓抑制和急诊/住院.
主要成果:
- 快速速率氧沙 (n=90) 与增加HSR或其他需要剂量修改的毒性无关.
- 然而,快速输液与永久性停药率较高的牛利platin相关 (7.8%对1.1%,p=0.032).
- 周围神经病变的发病率在快速发病率组显著更高 (72.2%对42%,RR2.09,p<.001).
结论:
- 快速服用牛利的结果是治疗变化很小,但外围神经病变显著增加.
- 周围神经病变的风险增加可能会超过更快的牛利普拉丁输液的好处.
- 需要进一步评估,以确定西在癌症治疗中的最佳输液速率.
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