对c-optimal实验设计的组合优化算法的评估与相关的观测
1Insitute of Applied Health Research, University of Birmingham, Birmingham, UK.
概括
组合优化算法有效地识别了c-最佳的实验设计,即使有相关的数据. 局部和反向贪搜索提供了强大的性能,优于通用线性混合模型的传统方法.
科学领域:
- 统计 统计 统计 统计
- 实验设计 实验设计
- 计算科学 计算科学
背景情况:
- 确定最佳的实验设计对于有效的数据收集至关重要.
- 实验单位内部和实验单位之间的相关性使设计优化变得复杂.
- 一般化的线性混合模型 (GLMMs) 经常用于分析复杂的实验数据.
研究的目的:
- 应用组合优化算法来识别c-最佳的实验设计.
- 为了评估本地搜索,贪搜索和反向贪搜索算法的性能.
- 扩展这些算法用于模型稳定性c-最佳设计.
主要方法:
- 制定c-最佳设计标准作为单调的超模块化函数.
- 应用最小化算法 (本地搜索,贪搜索,反向贪搜索) 以在GLMMs.Ms下找到最佳设计.
- 将算法性能与乘法权重方法进行比较.
主要成果:
- 当地搜索和反向贪搜索算法表现出相似的性能.
- 这些算法的设计输出显示,在各种协差结构中,差异比最好的设计大不到10%.
- 经过测试的算法表现与乘法方法一样好或比乘法方法更好.
结论:
- 组合优化为与相关数据的c-optimal实验设计提供了一个有效的框架.
- 本地和反向贪搜索算法对此任务是可靠和高效的.
- 开发的方法可以扩展到找到最佳的模型设计.
相关概念视频
Experimental Designs
11.6K
An experimental design is a systematic process that allows researchers to evaluate the relationship between dependent and independent variables. There are three widely used types of experimental design - pre-experimental design, true experimental design, and quasi-experimental design. In pre-experimental design, the researcher compares the data before and after some interventions or treatments. The true-experimental design has more than one purposefully created group, a commonly measured...
11.6K
Study Design in Statistics
8.3K
A study design is a set of techniques that allow a researcher to collect and analyze data from different variables defined for a specific research problem. Statistics is commonly for effective study design and more robust experiments,
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
Does aspirin reduce the risk of heart attacks? Is one brand of fertilizer more effective at growing roses than another? Is fatigue as dangerous to a driver as the influence of alcohol? Questions like these are answered using randomized experiments with proper...
8.3K
Correlation of Experimental Data
254
Dimensional analysis simplifies complex physical problems and guides experimental investigations, but it does not provide complete solutions. It identifies the dimensionless groups that influence a phenomenon, but experimental data is needed to establish the specific relationships and validate theoretical predictions.
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
For example, a spherical particle moving through a viscous fluid experiences drag. Dimensional analysis shows that the drag force depends on the particle's diameter, velocity,...
254
Factorial Design
13.1K
Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
13.1K
Crossover Experiments
2.9K
Crossover experiments, also called the repeated-measurements design, is a study design in which all experimental units are exposed to all treatments in different periods. Crossover experiments are generally used in psychology, the pharmaceutical industry, agriculture, and medicine.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
Crossover designs are performed even with smaller sample sizes since the samples can act as their controls. These are better than simple randomized trials since patients are exposed to all the treatments.
2.9K
Randomized Experiments
7.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
Simple randomization
Simple...
7.0K


