实验室检测结果与COVID-19患者需要重症监护的死亡率之间的关系
Ilkay Bahceci1, Filiz Mercantepe2, Omer Faruk Duran1
1Department of Clinical Microbiology, Faculty of Medicine, Recep Tayyip Erdogan University, Rize, TUR.
Cureus
|August 1, 2023
概括
高中性粒细胞计数,低淋巴细胞计数和高甲胺与严重的COVID-19患者的死亡率有关. 伴随性疾病和二次感染也增加了重症监护室死亡的风险.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 临床病理学 临床病理学
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致一系列疾病,从无症状病例到严重呼吸衰竭.
- 了解影响重症监护室 (ICU) 患者生存的因素对于管理2019年新冠肺炎疾病 (COVID-19) 至关重要.
研究的目的:
- 调查人口统计数据,并发症和实验室参数与COVID-19的ICU患者的存活率之间的关联.
- 确定在需要重症监护的严重COVID-19病例中死亡率的预测因素.
主要方法:
- 对236名通过RT-PCR诊断出SARS-CoV-2的ICU患者的回顾性分析.
- 在幸存者和非幸存者之间比较人口统计,并发症和实验室数据 (前素,CRP,白细胞,淋巴细胞,中性粒细胞计数,中性粒细胞与淋巴细胞的比率).
- 使用假设测试对生存关系的评估.
主要成果:
- 死亡率与年龄较大和男性性别有显著的关联.
- 中性粒细胞与淋巴细胞比率 (NLR) 升高,淋巴细胞数量低,以及高甲胺水平与死亡率有显著联系 (p<0.001).
- 并发症 (p=0.012) 和共感染 (p=0.002) 与死亡率的增加有关.
结论:
- 中性粒细胞计数,NLR,公素,淋巴细胞计数,并发症和二次细菌感染是COVID-19的ICU患者死亡率的重要预测因素.
- 这些发现突出了评估严重COVID-19预后的关键生物标志物和临床因素.
- 早期识别这些危险因素,可以帮助及时干预和管理策略危急病患者.
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