在Onabotulinum治疗后,老年女性的高空虚后残留体积的预测因素A 治疗严重过度活跃的膀,使用机器学习模型
Nobuo Okui1, Tadashi Ikegami2, Tatsuo Hashimoto3
1Dentistry, Kanagawa Dental University, Kanagawa, JPN.
Cureus
|August 1, 2023
概括
白天的频率,脆弱性和排泄效率差预测了老年妇女的高注射后尿留与过度活动的膀 (OAB) 接受治疗的内素A注射. 这些因素有助于预测OAB治疗的并发症.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
- 医疗信息学 医疗信息学
背景情况:
- 肠道上A注射对于过度活跃的膀 (OAB) 是常见的.
- 高余空后尿液 (PVR) 量是一种潜在的并发症,特别是在老年人中.
- 预测高PVR对于管理老年人OAB治疗结果至关重要.
研究的目的:
- 为了确定严重的OAB的老年妇女中高注射后PVR体积 (> 200毫升) 的预测因素.
- 评估机器学习模型在预测PVR量方面的有效性.
- 为OAB治疗的临床决策提供信息.
主要方法:
- 针对接受onabotulinumA注射的OAB老年妇女的观察性研究 (2020-2022年).
- 进行了尿动力学研究和症状评估.
- 随机森林和支持矢量机 (SVM) 模型是使用R代码开发的.
主要成果:
- 18.0%的患者在注射后出现PVR体积>200毫升.
- 重要的预测因素包括年龄,虚弱,OAB-湿,白天频率和夜尿.
- 机器学习模型确定了白天频率,脆弱性和空白效率作为关键预测因素,达到0.926.9的AUC.
结论:
- 白天的频率,虚弱和空白效率低下是严重的OAB在老年妇女的onabotulinumA注射后高PVR体积的显著预测因素.
- 机器学习模型有效地预测PVR体积,整合多种临床因素.
- 研究结果支持基于证据的管理和OAB的个性化治疗策略.
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