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Updated: Jul 20, 2025

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实施首个全面的州口服液药物测试计划,用于路边查和DUID案件的实验室测试 - - 一个5年审查

Curt E Harper¹, Jason S Hudson², Kristin Tidwell¹

¹Alabama Department of Forensic Sciences, 2026 Valleydale Rd, Hoover, AL 35244, USA.

Journal of analytical toxicology

|August 1, 2023

概括

口服液 (OF) 测试为药物影响驾驶调查提供了有价值的替代方案. 这项研究验证了路边查设备和实验室方法,发现OF对检测THC和可卡因等毒品有效.

科学领域:

法医毒理学法医毒理学
分析化学分析化学

背景情况:

口服液 (OF) 越来越被认为是药物影响驾驶 (DUID) 调查的关键标本.
现有的OF分析方法需要对执法应用进行全面的验证.

研究的目的:

实施和评估美国第一个全面的OF药物测试计划.
评估路边OF选设备和LC-MS-MS确认方法对DUID病例的性能.

主要方法:

对三种路边OF查设备 (Dräger DrugTest® 5000,Abbott SoToxa®,Randox Evidence MultiSTATTM) 的评价进行了评估.
对滥用药物和大麻素的两个定性液体染色体-并联质谱 (LC-MS-MS) 确认方法的验证.
在5年的案例工作中分析了OF和血液样本,以确定药物流行率和OF:血液比率.

主要成果:

三个路边的OF选设备被认为适合目的,对大多数向药物表现出高精度.
经过验证的LC-MS-MS方法在86%的目标中达到国家安全理事会的切断值.
在5年内,THC和可卡因在OF中显示出较高的检测率 (90%和97%) 与血液相比 (75%和44%),OF:血液比率超过原始药物的统一性.

结论:

口服液是DUID调查的可行的替代或补充样本.
在驾驶时间附近收集OF可以提高药理活性物质的检测.
当与血液分析相结合时,高的OF:血液比率为DUID调查提供了有价值的数据.

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