相关实验视频

Updated: Jul 20, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

与COVID-19相关的严重粘膜皮肤水泡喷发:一个病例系列

Allison E Miller¹, Donglin Zhang¹, Bridget E Shields¹

¹Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Pediatric dermatology

|August 1, 2023

概括

严重的粘膜皮质喷发,包括反应性传染性粘膜皮质喷发 (RIME),与SARS-CoV-2感染有关. 这项研究详细介绍了八个病例,突出显示了COVID-19患者口腔和其他粘膜的参与.

科学领域:

皮肤病学皮肤病学
传染性疾病传染性疾病
病毒学病毒学

背景情况:

粘膜皮质突发症,如多形红斑 (EM),反应性传染性粘膜皮质突发症 (RIME),史蒂文斯·约翰逊综合征 (SJS) 和有毒表皮解体 (TEN) 与感染有关.
有限的报告存在于与SARS-CoV-2 (COVID-19) 相关的粘膜皮肤喷发.

研究的目的:

为了呈现与SARS-CoV-2感染相关的严重粘膜皮肤水泡喷发的病例系列.
描述这些喷发的临床特征和潜在触发因素.

主要方法:

在六个高等医疗中心进行的回顾性病例系列.
纳入标准:EM,RIME,SJS或TEN的临床诊断,以及在爆发发发前4周内对SARS-CoV-2的阳性测试.
收集关于患者人口统计,临床发现和潜在的传染性触发因素的数据.

主要成果:

8名患者 (6名儿科,2名成人) 符合标准.
在85.7%的病例中诊断出反应性感染性粘膜皮肤喷发 (RIME).
观察到100%的口腔粘膜干扰,50%的眼睛,50%的泌尿器官和37.5%的皮肤干扰.
四名患者没有其他确定的传染性触发因素,而四名患者有同时或先前感染的证据.

结论:

COVID-19感染与严重的粘膜皮肤喷发有关,主要是RIME.
口腔粘膜干扰是一个一致的发现.
同时或先前的感染可能在这些喷发的发展中起作用.

关键词:

牛肉病,免疫学上的疾病.感染,病毒感染,病毒感染.粘膜疾病粘膜疾病

更多相关视频

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

相关概念视频

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...