皮层-皮层配对的关联性刺激调节表面腹腔前运动皮层-初级运动皮层的连接性影响精密抓握期间的运动皮层活动
Andrea Casarotto1,2, Elisa Dolfini2, Luciano Fadiga1,2
1IIT@UniFe Center for Translational Neurophysiology, Istituto Italiano di Tecnologia, Ferrara, Italy.
The Journal of physiology
|August 1, 2023
概括
用特定的定向电流刺激腹前运动皮层 (PMv) 和初级运动皮层 (M1),可以选择性地提高精确的抓握控制. 这种PMv-M1刺激的目标是表面M1神经元,这些神经元对精细运动技能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 大脑的可塑性 大脑的可塑性
背景情况:
- 腹前运动皮层 (PMv) 和主要运动皮层 (M1) 是用于握手的关键大脑区域.
- 了解PMv-M1连接如何区分动力和精密握柄对于电机控制研究至关重要.
研究的目的:
- 调查功能性PMv-M1连接如何影响动力和精密抓动作之间的区别.
- 探索PMv-M1皮层-皮层配对关联刺激 (cc-PAS) 在不同握力类型期间对皮层脊髓刺激性的影响.
主要方法:
- 应用PMv-M1 cc-PAS到M1使用前后 (PA) 和前后 (AP) 线圈方向来诱导可塑性.
- 在cc-PAS之前和之后的精度和动力抓地执行过程中,测量了发动机唤起的潜能 (MEP) 幅度,延迟和皮质静音期.
主要成果:
- 带有PA方向的PMv-M1 cc-PAS对两种抓类型都没有改变MEP或皮质静音周期.
- 具有AP方向的PMv-M1 cc-PAS具有专门调节的电机驱动器,用于精确的抓地力.
- AP刺激导致在精确抓握执行期间皮质脊髓刺激能力的选择性增加.
结论:
- 通过PMv输入激活的表面M1神经元群体,优先参与精确的抓动作.
- 通过塑性诱导协议针对特定的PMv-M1亚群,可能为手功能的康复提供转化价值.
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