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吸烟是否会在牙周炎症中影响托芬代谢? 一个横截面研究
Canan Önder1, Nihan Akdoğan1, Şivge Kurgan1
1Department of Periodontology, Faculty of Dentistry, Ankara University, Ankara, Turkey.
Journal of periodontal research
|August 1, 2023
概括
吸烟会通过改变托-金林代谢来恶化牙周炎症. kynurenine及其代谢产物显示出与吸烟和牙周病有关的潜在生物标志物.
科学领域:
- 生物化学 生化学
- 口腔健康 口腔健康
- 免疫学 免疫学 免疫学
背景情况:
- kynurenine 途径 (KP) 是酸 (TRP) 的主要代谢途径,也是牙周病的潜在生物标志物.
- 虽然研究了吸烟对KP代谢的影响,但其在通过KP导致的吸烟相关牙周病中的具体作用尚不清楚.
研究的目的:
- 为了研究吸烟和牙周炎症对托-金氨酸代谢的影响.
- 为了将这些代谢变化与临床 parodontal 参数相关联.
主要方法:
- 从牙周炎患者 (吸烟者和非吸烟者) 和牙周健康的对照人群中采集了唾液和血清样本.
- 分析了IL-6,kynurenine (KYN) 和tryptophan (TRP) 的水平,以及使用液态染色体质谱的KYN/TRP比率.
- 记录的临床牙周测量.
主要成果:
- 牙周炎组显示出更高的唾液TRP水平. 非吸烟者牙周炎患者的唾液KYN最高,唾液KYN/TRP比最低.
- 吸烟者表现出较低的血清KYN水平. 非吸烟者牙周炎患者的血清KYN/TRP比率和唾液IL-6水平较高.
- 吸烟加剧了牙周炎症,增加了TRP降解,并抑制了血清中的KP.
结论:
- 吸烟会加剧牙周炎症,并改变托的代谢.
- kynurenine及其代谢物可能作为连接吸烟和牙周病的重要生物标志物.
- 金氨酸通路与吸烟相关的牙周病的发病有关.
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