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Updated: Jul 20, 2025

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协调化学控制协酶B12 合成由人类腺三酸盐:Cob(I) 胺腺转移酶

Harsha Gouda1, Zhu Li1, Markus Ruetz1

  • 1Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.

Inorganic chemistry
|August 1, 2023
PubMed
概括

这项研究揭示了MMAB酶如何使用紧张的四坐标cob(II) 胺结构来促进维生素B12的化学反应. 这种独特的几何结构对于减少辅因子至关重要,影响MMAB患者的疾病机制.

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