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遗传和其他因素有助于在正牙患者的外部角根再吸收
Nellie N Baghaei1, Guihua Zhai2, Ejvis Lamani1
1Department of Orthodontics, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, USA.
Orthodontics & craniofacial research
|August 1, 2023
概括
ортодонтика治疗可能会导致外部角根再吸收 (EARR),这种情况与特定的基因变异 (如IL-1A rs1800587) 和治疗因素有关. 了解这些风险有助于在正义牙科护理期间管理EARR.
科学领域:
- 遗传学和正牙科 遗传学和正牙科
- 牙科研究 牙科研究
- 口腔健康 口腔健康
背景情况:
- 外部角根再吸收 (EARR) 是正牙治疗的一个常见的多因素并发症,可能导致显著的根缩短.
- 鉴定与EARR相关的遗传倾向和临床因素对于减轻正义牙科患者的不良结果至关重要.
研究的目的:
- 研究特定单核酸多态 (SNPs) 与正牙患者发展EARR的风险之间的关联.
- 评估患者和治疗相关因素对EARR发病率的贡献.
主要方法:
- 在阿拉巴马大学伯明翰牙科学院进行了一项病例对照研究.
- 全景射线图评估了EARR (≥20%的根长度损失). 分析的因素包括人口统计,牙科/骨分类,治疗细节和IL-1A,IL-1B,IL-1RN,P2RX7,IRAK1和CASP1.1中的SNP.
- 统计分析包括千平方,t测试,威尔科克森测试,FDR调整和后勤回归 (P < .05).
主要成果:
- 提取治疗和牙科分类与根部再吸收有显著的关联.
- IL-1A rs1800587的GG基因型,与增加的过喷气相结合,增加了高加索患者的EARR风险.
- 一种CASP1 (rs530537) 变种显示了增加风险的趋势 (P=.09),但在FDR调整后没有达到统计学意义.
结论:
- 患者特异性遗传因素和与治疗相关的变量都在EARR的发展中起作用.
- 这些发现凸显了在正义牙科期间管理EARR时考虑遗传倾向和治疗方案的重要性.
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