JGI植物基因图谱:可更新的转录组资源,以改善植物王国的功能基因描述
Avinash Sreedasyam1, Christopher Plott1, Md Shakhawat Hossain2
1HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.
Nucleic acids research
|August 1, 2023
概括
联合基因组研究所 (JGI) 的植物基因图谱通过分析18个植物物种的表达模式,为超过64,000个基因赋予了生物功能. 这个资源有助于理解基因功能,并通过基因编辑改进植物.
科学领域:
- 植物生物学 植物生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 基因功能对于理解特征变异和植物改进至关重要.
- 许多植物基因缺乏功能性注释,阻碍了研究和育种工作.
- 环境反应可以揭示基因功能,并提供基因修饰的目标.
研究的目的:
- 开发一个可更新的数据资源,即JGI植物基因图谱,用于分析各种植物物种的基因表达.
- 通过表达特征和环境响应数据,将生物信息分配给未注释的基因.
- 为访问和查询基因表达数据提供基于Web的平台.
主要方法:
- 收集了18种不同的植物物种的转录丰度测定.
- 分析表达特征,以识别特定于组织/疾病的基因集群.
- 测试了对环境线索的转录反应.
- 集成表达数据来推断未注释基因的功能.
主要成果:
- 发现了许多未注释基因的基因遗传学上受约束和特定条件的表达特征.
- 将表达式衍生生物信息分配给64,495个具有以前未知的功能的基因.
- 确定了密切共同表达的基因集群,揭示了保存的表达模式.
结论:
- 该JGI植物基因图谱显著扩大了植物基因的功能注释.
- 保存的表达模式为跨物种的基因功能提供了宝贵的见解.
- 该资源通过识别关键基因来促进基因编辑以改善植物.
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