淋巴管癌患者的神经复发症:一种描述性队列研究
Renuka Baloda1, Suvasini Sharma1, Rama Anand2
1Departments of Pediatrics.
Journal of pediatric hematology/oncology
|August 1, 2023
概括
神经系统并发症影响了近15%的患有淋巴细胞瘤恶性瘤的儿童,通常是在化疗期间. 及时治疗可以最大限度地减少这些儿童癌症患者的严重后果和死亡率.
科学领域:
- 儿科瘤学 儿科瘤学
- 神经瘤学神经瘤学
- 血液学 血液学 血液学
背景情况:
- 儿童的淋巴管恶性瘤面临着独特的挑战.
- 神经学并发症可能在诊断和治疗期间出现.
- 了解这些并发症对于患者管理至关重要.
研究的目的:
- 为了研究患有淋巴细胞恶性瘤的儿科患者的神经学并发症的频谱.
- 为了确定这些神经系统并发症的原因.
- 评估结果和管理策略.
主要方法:
- 一项描述性队列研究,涉及204名患有淋巴细胞瘤恶性瘤的儿童.
- 基线调查和评估神经症状,包括脑脊液检查,放射学和电生理学研究.
- 管理层遵循标准指导方针.
主要成果:
- 14.7%的患者 (30/204) 患有神经系统并发症,主要是在化疗期间 (87%).
- 常见的并发症包括甲甲酸神经毒性 (7),温克里斯神经毒性 (7),以及中枢神经系统 (CNS) 复发 (4).
- 70%的并发症通过治疗得到解决,而6.7%的并发症持续存在;13.3%的患者死亡.
结论:
- 儿科淋巴细胞恶性瘤的神经并发症是多样化的,呈现方式各不相同.
- 密切监测和有效干预是减少发病率和死亡率的关键.
- 早期检测和管理对于改善受影响儿童的结果至关重要.
更多相关视频
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
1.4K
06:03Integrating Augmented Reality Tools in Breast Cancer Related Lymphedema Prognostication and Diagnosis
Published on: February 6, 2020
6.7K
相关概念视频
Secondary Lymphoid Organs
1.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.6K
Primary Lymphoid Organs
1.6K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.6K
Development of the Lymphatic System
785
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
785
Lymphoid Cells and Tissues
1.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.2K
Lymphatic Vessels and Lymph Transport
3.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
3.7K
