在多哥,儿童患有状细胞病的严重急性细菌感染
Adama Dodji Gbadoé1,2,3, Koffi Mawuse Guédénon1,3, Magnoulelen N'zonou2
1Hemato-oncology Unit of the Pediatrics Department.
Journal of pediatric hematology/oncology
|August 1, 2023
概括
在患有状细胞疾病的儿童中,严重的细菌感染显示了致病细菌的转移. 大肠杆菌,肺炎菌和金黄色葡萄球菌越来越普遍,而沙门氏菌已经下降.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 细菌感染对患有状细胞疾病 (SCD) 的儿童构成重大风险.
- 这些感染是儿童SCD患者疾病和死亡的主要原因.
研究的目的:
- 评估严重急性细菌感染及其病原体在患有SCD的儿童中的分布.
- 这项评估是在引入13肺炎球菌合疫苗一年后进行的.
主要方法:
- 进行了对医疗记录的回顾性分析.
- 数据包括2015年1月1日至2019年12月31日期间入院的015岁儿童.
- 研究人员检查了洛美四个状细胞监测单位的记录.
主要成果:
- 腹肺感染最常见 (46.1%),其次是尿路感染 (32.8%) 和骨关节感染 (9.3%).
- 格拉姆阴性生物,特别是大肠杆菌 (31.6%) 和肺炎菌 (18%),占主导地位,经常导致尿路和骨关节感染.
- 金黄色葡萄球菌是多发性肺炎感染 (40%),骨关节感染 (47.3%) 和败血症 (28.6%) 中最常见的病原体.
结论:
- 虽然在儿科SCD患者中常见的感染仍然存在,但微生物环境正在发生显著的转变.
- 在沙门氏菌感染的减少和由大肠杆菌,Klebsiella肺炎和黄金葡萄球菌引起的感染的同时增加.
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