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在接受仿真抗原受体-T细胞治疗后的患者中发现异常的骨髓发现

Cecilia C S Yeung^1,2, David W Woolston¹, Vicky Wu³

¹Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

European journal of haematology

|August 1, 2023

概括

在CAR-T细胞治疗后的骨髓活检显示出显著的变化,包括低细胞性和缩. 骨髓囊细胞和网球蛋白的增加与患者的生存结果较差有关.

科学领域:

血液学血液学血液学
免疫治疗是一种免疫疗法.
在瘤学瘤学.

背景情况:

骨髓评估不是标准的CAR-T细胞输液后监测不良事件的标准.
我们的机构经常在治疗前,治疗后以及随访期间进行骨髓活检.

研究的目的:

在CAR-T细胞免疫疗法后系统地审查骨髓异常.
为了将骨髓发现与患者的死亡率和复发等结果相关联.

主要方法:

259名CAR-T输液后患者的骨髓样本的回顾性审查.
骨髓病理与死亡率,复发/残留疾病以及实验室值的相关性.

主要成果:

在输液后35.5天,25.5%的患者表现出严重的骨髓低细胞性和6.2%的血清性缩.
淋巴细胞,巨细胞或粒状细胞反应的增加与疾病负担的减少有关.
骨髓囊细胞增加和2-3级的网球蛋白与较低的整体存活率相关 (p < 0.05).

结论:

这项研究提供了对接受CAR-T细胞免疫治疗的患者骨髓变化的第一个系统观察.
骨髓发现可以为用CAR-T细胞治疗的患者提供预后见解.

关键词:

收养免疫疗法采用免疫疗法.骨髓骨髓骨髓骨髓骨髓嵌合式抗原受体嵌合式抗原受体临床病理学临床病理学免疫疗法免疫疗法病理学的病理学手术病理学的外科病理学

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