早期视觉丧失会影响视觉腹腔流的功能发展
Yifan Xiang1, Jingwen Yang2,3, Leyan Gao2
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Vision Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Investigative ophthalmology & visual science
|August 1, 2023
概括
患有早期视力丧失 (VD) 的儿童在白内障移除后显示神经处理发生变化. 他们的视觉皮层和腹部流的激活率较低,前部区域补偿,影响视觉恢复.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 视觉处理 视觉处理
背景情况:
- 早期视觉剥夺 (VD) 可以影响神经网络的发展.
- 了解VD后的实时视觉处理变化对于有效的干预至关重要.
研究的目的:
- 为了研究神经网络的动态变化,在早期的双眼视觉疾病移除后的实时视觉处理.
- 为了比较视觉处理在儿童有史以来的VD与典型的发展 (TD) 的儿童.
主要方法:
- 展望横截面研究,涉及20名患有早期VD的儿童和20名TD的儿童.
- 高密度脑电图 (EEG) 用于记录与事件相关的潜能 (ERP).
- 分析ERP组件 (P1,N170,P2) 跨对象,面孔和角色刺激,使用源定位和阿尔法功率分析.
主要成果:
- 与TD儿童相比,患有VD的儿童在左侧部和部区域呈现出明显较低的P1幅度.
- 源源地图显示,视觉皮层和腹部流中的激活减少在VD组.
- 额头区域在VD组中显示出功能补偿的参与增加,在对象识别过程中显著的α脱同步.
结论:
- 早期的双筒VD去除导致视觉网络动态的明显改变.
- 结果表明视觉恢复较差的基础,并为开发视觉康复策略提供了见解.
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