乳制品蛋白质的骨安全性:随机对照试验的元分析
Khemayanto Hidayat1, Xing Tong2, René Rizzoli3
1Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, China. khemzie_khem@yahoo.com.
概括
这次元分析发现,牛奶蛋白质补充剂不会损害骨健康. 这项研究表明,乳制品蛋白对成年人骨密度和相关生物标志物是安全的.
科学领域:
- 营养科学 营养科学
- 骨的新陈代谢 骨的新陈代谢
- 临床研究 临床研究
背景情况:
- 一个持久的说法表明,乳制品蛋白质出,可能会损害骨健康.
- 这一说法受到质疑,需要对乳制品蛋白质的骨安全性进行科学评估.
研究的目的:
- 进行随机对照试验 (RCT) 的元分析.
- 评估乳制品蛋白质补充剂对成年人骨健康指数的影响.
- 解决关于乳制品蛋白质骨安全性的争议.
主要方法:
- 在PubMed和Web of Science中搜索相关的RCT.
- 使用随机效应模型计算聚合效应大小和95%置信区间.
- 分析了多项关于骨矿物质密度 (BMD) 和生化标志物的RCT的数据.
主要成果:
- 乳制品蛋白质补充剂对全身BMD或腰椎,部,大腿部,三叉体,三叉体间或超远半径的BMD没有显著影响.
- 关键的骨形成和再吸收标记,以及副甲状腺激素水平,没有受到影响.
- 胰岛素样生长因子-1 (IGF-1) 度增加,特别是与大豆蛋白或碳水化合物补充剂相比.
结论:
- 该研究的结果不支持牛奶蛋白对骨健康有害的说法.
- 乳制品蛋白似乎对成年人的骨健康是安全的.
- 进一步的研究可能会探索IGF-1对乳制品蛋白质摄入的细微影响.
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