有证据表明,RA依赖于甲状腺炎的化发生在海胚胎中
Kaiyue Wu1, Qiran Chen2,3, Fang Li1
1College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, China.
Cell and tissue research
|August 1, 2023
概括
乌中介质症的发作仅限于雌性,由升高的视网膜酸 (RA) 水平引发. 这项研究阐明了胚胎细胞的发育和RA.
科学领域:
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
- 进行比较基因组学.
背景情况:
- 介质形成的开始是脊椎动物生殖细胞中关键的早期性别决定事件.
- 虽然在哺乳动物,鸟类和鱼类中进行了研究,但爬行动物中转化仍然不太了解.
- 了解爬行动物的半变化为脊椎动物的繁殖进化提供了洞察力.
研究的目的:
- 为了研究红耳滑中化开始的分子机制.
- 确定视网膜酸 (RA) 在启动乌生殖细胞中中离合的作用.
- 为了比较雄性和雌性海胚胎之间的半变异启动.
主要方法:
- 利用Stra8作为胚胎性淋巴体中预兆性转移的指标.
- 在特定的发育阶段检测到变标志物Sycp3的表达.
- 分析了RA合成 (Aldh1a1) 和降解 (Cyp26a1) 酶的表达.
- 在体内和体外给予外源性RA治疗.
主要成果:
- 雌性海性腺体的半月体结合在第19阶段左右开始,Sycp3的表达增加到第23阶段.
- 在男性胚胎性腺体中没有观察到介质基因表达,这表明性别特异性进入介质变异.
- 雌性淋巴体表现出更高的Aldh1a1和较低的Cyp26a1表达,这表明在介质进入之前RA活性升高.
- 外源性 RA 治疗诱导了 Stra8 和 Sycp3 两性表达.
结论:
- 红耳滑动的半转化启动仅限于胚胎雌性生殖细胞.
- 胚胎雌性性腺体中升的视网膜酸 (RA) 水平驱动了半衰期的开始.
- 这项研究阐明了RA在乌生殖细胞发育中的作用,并为爬行动物半分裂提供了一个模型.
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