在帕金森病的非运动波动中性别差异
Giulia Donzuso1, Calogero Edoardo Cicero1, Erica Vinciguerra1
1Department of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Via Santa Sofia 78, 95123, Catania, Italy.
Journal of neural transmission (Vienna, Austria : 1996)
|August 1, 2023
概括
非运动波动 (NMF) 显著影响帕金森病 (PD) 患者. 这项研究发现,患有PD的女性更有可能经历NMF,这表明需要性别特定的护理策略.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 老年病的医生 老年病的医生
背景情况:
- 非运动症状 (NMS) 和非运动波动 (NMF) 在帕金森病 (PD) 中很普遍,显著影响患者的生活质量.
- 了解NMF的负担和模式对于有效的PD管理至关重要.
研究的目的:
- 估计帕金森病患者中NMF的患病率和负担.
- 调查性别对PD中NMF发生和特征的潜在影响.
主要方法:
- 使用非运动波动评估问卷 (NoMoFA) 评估121名符合MDS-PD标准的PD患者.
- 将NoMoFA项目分组为认知,情绪,睡眠/疲劳,失调,幻觉/感知和各种领域.
- 进行了多变量分析,以确定与NMF相关的因素.
主要成果:
- 所有PD患者报告至少有一次NMS; 71.9%报告NMF.
- "感到惰或能量不足" (47.2%) 和"白天嗜睡" (40.0%) 是最常见的NMF.
- NMF与女性性别有显著的相关性 (调整后OR 3.13,p=0.01),女性在抑郁症/焦虑症,睡眠/疲劳和dysautonomia领域报告的得分更高.
结论:
- 在PD患者的NMS和NMF频率中存在与性别相关的模式.
- 女性性别与在帕金森病中发展NMF的风险增加有关.
- 个性化治疗策略对于解决NMF至关重要,特别是考虑到性别差异.
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