治疗期间和治疗后的维生素D状况以及卵巢癌存活率
Tanya L Ross1,2, Rachel E Neale3,4, Renhua Na3,4
1Population Health Program, QIMR Berghofer Medical Research Institute, Brisbane, Australia. Tanya.Ross@qimrberghofer.edu.au.
Cancer causes & control : CCC
|August 1, 2023
概括
血清维生素D水平与卵巢癌存活率无关. 这表明补充维生素D不需要在没有缺乏症的患者中改善结果.
科学领域:
- 在瘤学瘤学.
- 营养生物化学 营养生物化学
- 流行病学 流行病学
背景情况:
- 卵巢癌的生存率仍然低于最佳水平,需要改进治疗策略.
- 血清25-氧维生素D [25(OH) D]水平,维生素D状态的标志物,已显示与改善各种癌症的存活率有关.
- 关于25(OH) D对卵巢癌存活率的影响的数据有限.
研究的目的:
- 为了研究在初级治疗期间和之后的血清25(OH) D度与卵巢癌特异性生存率之间的关联.
- 为了确定维生素D状态是否会影响接受卵巢癌化疗的妇女的结果.
主要方法:
- 一项全国范围的前性队列研究包括886名卵巢癌妇女接受化疗治疗.
- 在初级治疗期间和/或之后,从700名参与者的血清样本中分析了25...OH) D度.
- 使用多变量Cox比例危险回归来评估25~OH) D水平与卵巢癌特定存活率之间的关系.
主要成果:
- 治疗期间平均25(OH) D度为82nmol/L,治疗后为91nmol/L,缺乏的流行率很低 (低于50nmol/L).
- 在血清25(OH) D度和卵巢癌特定的5年生存率之间没有发现显著的关联.
- 对于最高与最低五分位数的25(OH) D的危险比率在治疗期间为1.10和治疗后为0.95.
结论:
- 在这种队列中,血清25 ((OH) D度与卵巢癌特异性存活率无关.
- 在没有维生素D缺乏症的患者中,维生素D补充可能对改善卵巢癌存活率没有好处.
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