在一项随机双盲临床试验中,可可黄醇改善了高峰VO和运动能力,该试验对健康的老年人进行了随机双盲临床试验
Michael Gröne1, Dragos Andrei Duse1, Nicolas Kramser1
1Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany. Ralf.Erkens@med.uni-duesseldorf.de.
Food & function
|August 1, 2023
概括
可可黄素 (CF) 在健康的老年人中显著改善心肺呼吸能力并降低血压. 这种饮食干预显示出在老年人群中保持心血管健康的潜力.
科学领域:
- 心血管衰老和运动生理学
- 营养科学和老年学
背景情况:
- 心血管衰老的特点是功能能力下降,与年龄相关的血压和炎症增加.
- 老年人功能性运动能力下降与心血管健康标志物的恶化有关.
- 已知可可黄 (CF) 对内皮功能,血压和炎症有积极的影响.
研究的目的:
- 评估可可黄 (CF) 对健康老年人的心肺健康的影响.
- 调查CF补充剂是否可以提高运动能力和改善老年人心血管健康标志物.
主要方法:
- 一个随机的,双面罩的,安慰剂控制的试验,涉及68名健康的老年参与者 (55-79岁).
- 参与者每天两次服用500毫克CF或安慰剂,持续30天.
- 通过心肺运动测试 (CPET) 期间的峰值氧气消耗 (VO2) 评估心肺呼吸能力,其次要终点包括氧气脉冲,血压和血管功能.
主要成果:
- 可可黄的摄入导致高峰氧气消耗 (VO2) 显著增加190毫升/分钟,高峰VO2每公斤增加2.5毫升/分钟.
- 氧气脉冲和最大运动能力也随着CF补充而显著改善.
- 摄入CF降低了静止系统和透气血压,并增加了流量介导血管扩张 (FMD) 的1.3%.
结论:
- 可可黄素在健康的老年人中显著改善心肺健康指标.
- 补充CF证明了在保持心血管健康和增强衰老期间功能能力的潜力.
- 这些发现表明CF是一种有前途的饮食干预措施,用于支持老年人心血管健康.
更多相关视频
14:39Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
4.0K
09:19Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice
Published on: February 2, 2019
9.9K
相关概念视频
01:20Exercise and Cardiovascular Response
866
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
866
01:47Lung Capacity
50.7K
The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
50.7K
01:26Coronary Artery Disease IV: Preventive Measures
24
Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
24
01:26Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
01:17Exercise and Cardiac Output
1.1K
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
1.1K
01:25Pulmonary Function Tests
371
Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
371