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基因组规模甲基化分析确定了免疫特征和年龄加速与膀癌结果的关联
Ji-Qing Chen1, Lucas A Salas1, John K Wiencke2
1Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire.
概括
详细的免疫细胞简介和生物衰老加速与膀癌存活率有关. 较高的CD8T记忆细胞改善了生存率,而中性粒细胞和年龄加速使其恶化,提供了新的预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 免疫特征会影响膀癌的预后.
- 详细的免疫细胞亚型及其在膀癌中的预后价值需要进一步探索.
研究的目的:
- 研究详细的免疫细胞亚型,年龄加速和膀癌患者结局之间的关联.
- 为了确定膀癌复发和生存的潜在预后生物标志物.
主要方法:
- 使用Illumina HumanMethylationEPIC阵列分析了外周血液DNA甲基化.
- 细胞类型解量化了12个免疫细胞比例;DNA甲基化钟评估了生物年龄.
- 考克斯模型和机器学习算法 (partDSA,SS-RPMM) 分析了与生存的关联.
主要成果:
- 较高的CD8T记忆细胞比例与更好的整体存活率相关.
- 增加中性粒细胞与淋巴细胞的比率,CD8T原始细胞,中性粒细胞和衰老加速与更糟糕的整体存活率有关.
- 机器学习模型识别了具有显著生存差异的不同患者组.
结论:
- 特定的甲基化衍生的免疫细胞比例和年龄加速与膀癌的结果有关.
- 这些因素表明,它们有可能成为膀癌的预后生物标志物.
相关概念视频
01:46Epigenetic Regulation
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
01:37Epigenetic Regulation
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...