当你需要深入研究时-移植SARS-CoV-2 PCR+接收者
Sofia Zavala1, Clare DeLaurentis2, Justin G Aaron2
1Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.
概括
在急性冠状病毒病2019 (COVID-19) 期间移植器官对于精选的,症状最小的,非肺接受者来说是安全的. 阳性SARS-CoV-2 PCR的患者可以接受紧急移植,结果良好.
科学领域:
- 移植手术 移植手术
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 有时在患有活跃的2019年新冠病毒病 (COVID-19) 的患者中需要紧急器官移植.
- 了解急性COVID-19期间移植的安全性对于患者管理至关重要.
研究的目的:
- 评估已故供体器官移植在非肺接受者中,在移植时呈阳性SARS-CoV-2聚合酶连锁反应 (PCR) 试验的安全性和结果.
- 评估与COVID-19相关的并发症和这个队列中的移植/患者存活率.
主要方法:
- 从两个移植中心 (01/01/2022至02/01/2023) 收集非肺移植接受者在移植日呈阳性SARS-CoV-2 PCR的回顾性数据.
- 包括人口统计数据,COVID-19细节,等候名单优先级和移植细节.
- 收集数据的描述性分析.
主要成果:
- 十二名患者 (7个脏,4个肝脏,1个心脏) 接受了移植,而疫苗接种和COVID-19阳性.
- 十个无症状患者立即移植;两名患有轻度症状的住院患者接受了雷梅西维尔,并在临床改善后移植.
- 没有观察到与COVID-19相关的并发症或二次感染. 移植和患者存活率为100%,随访时间中位数为143天.
结论:
- 已故捐赠者器官移植可以安全地在精选的,症状最小的,非肺接受者中进行,这些接受者对SARS-CoV-2的检测结果呈阳性.
- 仔细选择患者,隔离预防措施和抗病毒治疗 (如有指示) 是成功结果的关键.
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