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对于治疗功能衰竭中高酸血症的药物治疗的进展

Valeria Cernaro¹, Elisa Longhitano¹, Vincenzo Calabrese¹

¹Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Expert opinion on pharmacotherapy

|August 1, 2023

概括

在慢性病 (CKD) 中管理高酸血是至关重要的. 酸盐结合剂有助于控制血清酸盐,但了解它们的各种影响和副作用对于有效的CKD-矿物骨障碍 (CKD-MBD) 治疗至关重要.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
内分泌学在内分泌学.
药理学药理学是指药理学的学科.

背景情况:

慢性病-矿物骨疾病 (CKD-MBD) 是慢性病 (CKD) 的主要并发症,导致显著的发病率和死亡率.
和代谢的异常发生在CKD的早期,在晚期,高血症变得突出.
超酸血与心血管疾病和CKD进展有关,部分由纤维细胞生长因子23 (FGF23) 介导.

研究的目的:

审查随机临床试验和对慢性病中低酸盐疗法的元分析.
强调了解各种酸盐结合剂的安全性概况和代谢作用的重要性.
强调饮食中酸盐限制在控制血清酸盐和相关激素中的作用.

主要方法:

在PubMed数据库的系统文献搜索.
包括随机临床试验和对研究低酸盐疗法的元分析.
对药物安全性概况,对/代谢的影响以及血管化的分析.

主要成果:

酸盐结合剂在安全性和对/酸盐代谢和血管化的影响方面有所不同.
关于酸盐降低剂,特别是新药的临床结果的数据有限,有时存在争议.
饮食中酸盐的限制对于控制血清酸盐水平正常时至关重要,以及管理FGF23和副甲状腺激素 (PTH).

结论:

对酸盐结合剂的深入了解对于最佳的CKD患者管理至关重要.
酸盐结合剂可以帮助控制血清酸盐,但可能有副作用和不同的临床结果数据.
减少饮食中酸盐摄入量在控制血清酸盐和相关激素失衡中起着关键作用.

关键词:

心血管疾病是什么心血管疾病联邦政府财政基金23 死亡率死亡率低酸盐药物可以降低酸盐.血管化血管化

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