性结肠炎患者患上性脊柱炎的发展:一个系统的元分析
Aitao Lin1, Yongyi Tan1, Jinxia Chen1
1Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China.
性结肠炎患者患上性脊柱炎的可能性为1.66%. 这种风险随着随访时间的延长而增加,并且在具有阳性人类白细胞抗原B27.7的人群中更高.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 是一种影响肠道的炎症性肠病 (IBD).
- 化脊柱炎 (AS) 是一种炎症状况,影响神经关节.
- 在一些患者中,已知存在从UC到AS的进展.
研究的目的:
- 在性结肠炎 (UC) 患者中调查性脊柱炎 (AS) 的患病率.
- 对现有的关于UC向AS进展的文献进行元分析.
- 确定与UC患者AS发展相关的风险因素.
主要方法:
- 在PubMed,科学网络,Embase和Cochrane图书馆 (成立时间:2022年12月) 进行了全面的文献搜索.
- 研究的选基于严格的纳入和排除标准.
- 使用包括森林地块和I2统计数据在内的元分析技术来评估AS发病率和异质性.
主要成果:
- 分析了包括98,704名UC患者在内的17项研究.
- 在UC患者中,AS的总发病率为1.66% (95% CI:0.892.62%).
- 人类白细胞抗原B27 (HLA-B27) 阳性与AS风险增加显著相关 (RR:22.17) 在AS患者中更高 (68.29%).
- 随着随访时间的延长,AS发病率增加 (1.75%为≥5年,而1.41%为<5年).
结论:
- 性结肠炎患者面临患上性脊柱炎的风险较高.
- 阳性HLA-B27状态是IBD患者AS发展的重要风险因素.
- 在UC患者中,AS的发病率似乎随着随访时间的延长而增加.
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