身体活动状态和智力的因果关系:双向的门德尔随机化研究
Zhangmeng Xu1, Furong Zhang1, Guorong Qiu2
1Department of Health Preservation and Rehabilitation, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
PloS one
|August 1, 2023
概括
身体活动和智力有双向的因果关系. 虽然减少屏幕时间 (LST) 可能会降低智力,但屏幕时间行为 (SBW) 可能会增加智力,尽管存在反向因果关系.
科学领域:
- 遗传学 是一个遗传学.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 观察性研究将身体活动 (PA) 与增强的智力和久坐行为 (SB) 与认知风险联系起来.
- 在PA/SB和情报之间的因果关系仍然不清楚.
研究的目的:
- 通过使用孟德尔随机化 (MR) 研究各种身体活动状态对智力的因果关系.
- 探索不同体力活动特征对认知功能的独立影响.
主要方法:
- 采用孟德尔随机化 (MR) 和反变量加权 (IVW) 作为主要方法.
- 使用补充MR方法 (加权中位数,MR-Egger,MR-PRESSO) 进行灵敏度分析.
- 进行多变量MR,以评估身体活动特征的独立影响.
主要成果:
- 较少的屏幕时间 (LST) 与智力有负面关联 (β = -0.133,p = 1.34×10-9).
- 在工作期间的久坐行为 (SBW) 表明对智力有潜在的积极影响 (β = 0.261,p = 0.011).
- 智力显著影响了所有身体活动状态,表明了反向因果关系.
结论:
- 身体活动状态和智力之间存在双向因果关系.
- 研究结果表明,生活方式行为与认知功能之间存在复杂的相互作用.
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