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相关概念视频

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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相关实验视频

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Pattern-based Search of Epigenomic Data Using GeNemo
06:38

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

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完全隐私的安全搜索引擎由高效的基因组映射算法提供动力.

Yuan-Yu Chang, Sheng-Tang Wong, Emmanuel O Salawu

    IEEE journal of biomedical and health informatics
    |August 1, 2023
    PubMed
    概括

    这项研究介绍了Sapiens Aperio Veritas引擎 (S.A.V.E. ),一种使用完整文章作为查询的新搜索方法. 这就是S.A.V.E.E. 通过不披露搜索内容来确保用户隐私,为传统搜索引擎提供安全的替代方案.

    科学领域:

    • 计算机科学 计算机科学
    • 信息检索 信息检索
    • 生物信息学是一种生物信息学.

    背景情况:

    • 传统的搜索引擎依赖于关键字查询,暴露用户数据和搜索历史.
    • 现有的搜索方法缺乏强大的隐私保护,经常利用用户数据进行定向广告或数据库扩展.

    研究的目的:

    • 为了引入一种新的搜索和抄袭检测系统,Sapiens Aperio Veritas引擎 (S.A.V.E. ),优先考虑用户隐私.
    • 使用户能够在互联网上搜索,并使用完整的文章作为查询进行抄袭检查,而不会泄露内容.

    主要方法:

    • 开发了SAVE,采用编码方案和FM-index搜索,根据下一代基因组测序进行了调整.
    • 在用户的设备上使用12个"氨基酸"将查询词转换为伪生物序列 (PBS).
    • 通过提交本地生成的PBS与维基百科和开放访问期刊数据库对比,利用云服务进行抄袭检查.

    主要成果:

    • 这就是S.A.V.E.E. 准确地检测出相同的含量,对于超过12个"氨基酸"的PBS,错误阳性不到0.8%.
    • 该系统的基因组映射速度与Bowtie相美,比BLAST快5个数量级.
    • 这就是S.A.V.E.E. 提供标准和私人搜索模式,增强用户的机密性.

    更多相关视频

    A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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    A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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    Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
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    Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

    Published on: June 28, 2018

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    Last Updated: Jul 20, 2025

    Pattern-based Search of Epigenomic Data Using GeNemo
    06:38

    Pattern-based Search of Epigenomic Data Using GeNemo

    Published on: October 8, 2017

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    A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
    09:10

    A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

    Published on: May 22, 2018

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    Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
    09:14

    Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

    Published on: June 28, 2018

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    结论:

    • 这就是S.A.V.E.E. 介绍了一种革命性的,以隐私为首的搜索和抄袭检查系统.
    • 该方法为未来的搜索引擎创造了先例,这些搜索引擎的设计优先考虑用户的保密性.
    • 该系统可以在https://dyn.life.nthu.edu.tw/SAVE/.tw上访问.