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Updated: Jul 20, 2025

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多种癌症从多种MAPK路径抑制剂中逃脱出来,并使用DNA复制应激信号来容忍异常细胞周期

Timothy E Hoffman1, Varuna Nangia1,2, C Ryland Ill1

  • 1Department of Biochemistry and Biofrontiers Institute, University of Colorado Boulder, Boulder, CO 80303, USA.

Science signaling
|August 1, 2023
PubMed
概括

许多MAPK路径突变癌症通过恢复增殖来适应BRAF抑制剂. DNA修复途径有助于这些"逃生"细胞存活,这表明长期治疗癌症的新治疗点.

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