对诺卡迪亚物种抗微生物耐药性的表型和基因型分析
Yizhak Hershko1,2, Katia Levytskyi1, Ella Rannon3
1Koret School of Veterinary Medicine, Robert H. Smith Faculty for Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel.
The Journal of antimicrobial chemotherapy
|August 1, 2023
概括
诺卡迪亚的抗菌素耐药性很常见,通常与特定物种有关. 这项研究确定了耐药性基因和突变,揭示了诺卡迪亚抗生素耐药性的特定物种模式.
科学领域:
- 医学微生物学 医学微生物学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 抗微生物耐药性是治疗诺卡迪亚感染的一个重大挑战.
- 对于诺卡迪亚耐药性特征背后的分子机制的了解有限.
研究的目的:
- 为了确定诺卡迪亚临床分离物种的物种分布.
- 为了分析抗微生物敏感性模式.
- 调查诺卡迪亚物种中抗菌素耐药性的基因型决定因素.
主要方法:
- 来自以色列微生物学实验室的138种临床诺卡迪亚菌株的分析.
- 苏微稀释以确定12种抗菌剂的最小抑制度 (MIC).
- 全基因组测序 (WGS) 和生物信息学分析用于基因和抗性基因/突变的识别.
主要成果:
- 诺卡迪亚cyriacigeorgica是最常见的物种 (36%).
- 莱涅佐利德显示出普遍的活性;三甲烯/硫甲醇 (93%) 和阿米卡 (91%) 也具有高度的有效性.
- 特定物种的耐药性与已识别的基因/突变有关,包括 aph(2′′), blaAST-1, blaFAR-1, gyrA 替代和 16S rRNA 甲基转移酶.
结论:
- 该研究提供了关于诺卡迪亚物种,耐药性概况和分子耐药性机制的全面概述.
- 诺卡迪亚的抗菌素耐药性模式似乎与物种有关,这表明耐药性的新演变或传播有限.
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