一个用于磁驱动药物输送的软囊,基于硬磁弹性体泡
Xiao Sun1,2, Pan Zhang1,2, Zi Ye1
1Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
ACS biomaterials science & engineering
|August 1, 2023
概括
一个新的磁反应弹性体泡囊使得准确的,按需的药物输送. 这种软机器人技术提供可预测的药物释放,以改善生物医学应用中的剂量调节.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 软机器人软机器人 软机器人软机器人
背景情况:
- 多孔软生物材料用于刺激响应药物释放.
- 磁响应材料提供实时控制,但缺乏可预测的释放配置文件.
- 精确的剂量调节仍然是当前磁性药物输送系统面临的挑战.
研究的目的:
- 开发一种磁性控制的按需药物输送系统.
- 创建具有可预测和可重复的药物释放配置文件的软囊.
- 为了展示这个系统作为软机器人的潜力,用于体内药物输送.
主要方法:
- 使用灵活的硬磁弹性体泡 (HEF) 制造软囊,其毛孔相互连接.
- 使用预压缩磁化来实现HEF的显著压缩变形.
- 磁场应用以控制变形,从而控制药物释放率.
- 测试囊的药物释放可预测性和剂量调节精度.
- 在人类胃模型中评估囊作为磁驱动软机器人的性能.
主要成果:
- 在HEF囊中,药物释放率可调节,从0.02到1.7毫升/分钟.
- 药物释放特征被准确地预测,在剂量调节中准确度为85%.
- 达到90%以上的最大累积药物释放.
- 在人类胃模型中成功执行磁驱动药物输送.
- 该HEF材料具有较低的弹性模量 (10kPa) 和81%的相互连接的孔隙.
结论:
- 开发的HEF囊可实现精确的,按需的药物输送,可预测的释放动力学.
- 这项技术在治疗应用中对药物剂量进行调节方面取得了重大进展.
- 该HEF囊显示承诺作为一个多功能软机器人,用于人体内的各种生物医学应用.
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