调解中的共变量对效果量度的修改:扩展基于回归的因果调解分析.
Yi Li1,2, Maya B Mathur3, Daniel H Solomon2,4,5
1From the Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, Faculty of Medicine, McGill University, Montreal, QC, Canada.
Epidemiology (Cambridge, Mass.)
|August 1, 2023
概括
本研究引入了一种用于因果调解分析的新方法,该方法解释了基线特征如何修改效应. 这种方法提供了更准确的直接和间接影响的估计,与传统方法不同.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 传统的调解分析假定患者特征的效应是恒定的.
- 调查见解经常表明基线因素对效果的修改.
- 修改自然直接效应 (NDE) 和自然间接效应 (NIE) 等调解效应具有临床意义.
研究的目的:
- 扩展基于回归的因果调解分析,以纳入效果测量修改 (EMM).
- 评估基线特征如何改变NDE,NIE和比例介导.
- 为实现EMM在调解分析中提供一个实用的工具.
主要方法:
- 扩展基于闭式回归的因果调解分析,包括EMM.
- 使用模拟数值示例来展示方法的性能.
- 将扩展方法应用于针对减少贫血的抗干白素-1疗法的经验案例研究.
主要成果:
- 忽视EMM的天真调解分析可以产生偏见的NDE和NIE估计.
- 基线特征显著影响NDE和NIE的EMM的存在和程度.
- 通过炎症生物标志物介导的比例在年轻的非糖尿病患者中较高,患者的基线炎症较低.
结论:
- 在因果调解分析中考虑EMM对于准确的效果估计至关重要.
- 这些发现突出了基于患者特征的生物标志物的差异效用.
- 提供了一个开源的R包,regmedint,以促进EMM在研究中的采用.
相关概念视频
Multiple Regression
3.0K
Multiple regression assesses a linear relationship between one response or dependent variable and two or more independent variables. It has many practical applications.
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
Farmers can use multiple regression to determine the crop yield based on more than one factor, such as water availability, fertilizer, soil properties, etc. Here, the crop yield is the response or dependent variable as it depends on the other independent variables. The analysis requires the construction of a scatter plot...
3.0K
Strategies for Assessing and Addressing Confounding
119
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
119
Friedman Two-way Analysis of Variance by Ranks
240
Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures...
240
Regression Analysis
5.8K
Regression analysis is a statistical tool that describes a mathematical relationship between a dependent variable and one or more independent variables.
In regression analysis, a regression equation is determined based on the line of best fit– a line that best fits the data points plotted in a graph. This line is also called the regression line. The algebraic equation for the regression line is called the regression equation. It is represented as:
In regression analysis, a regression equation is determined based on the line of best fit– a line that best fits the data points plotted in a graph. This line is also called the regression line. The algebraic equation for the regression line is called the regression equation. It is represented as:
5.8K
What is an Experiment?
11.8K
An experiment is a planned activity carried out under controlled conditions. The purpose of an experiment is to investigate the relationship between two variables. When one variable causes change in another, we call the first variable the explanatory or independent variable. The affected variable is called the response or dependent variable. In a randomized experiment, the researcher manipulates values of the explanatory variable and measures the resulting changes in the response variable. The...
11.8K
Two-Way ANOVA
2.7K
The two-way ANOVA is an extension of the one-way ANOVA. It is a statistical test performed on three or more samples categorized by two factors - a row factor and a column factor. Ronald Fischer mentioned it in 1925 in his book 'Statistical Methods for Researchers.'
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
The two-way ANOVA analysis initially begins by stating the null hypothesis that there is an interaction effect between the two factors of a dataset. This effect can be visualized using line segments formed by joining the...
2.7K


