菌群生物组:与宿主相互作用以及对疾病的影响
Yani Fan1, Lijuan Wu2, Bing Zhai3
1Clinical laboratory, Shenzhen Bao'an Women's and Children's Hospital, Shenzhen, Guangdong Province, China; Maternal-Fetal Medicine Institute, Shenzhen Bao'an Women's and Children's Hospital, Shenzhen, China; CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Current opinion in microbiology
|August 1, 2023
概括
人类的真菌生物组,粘膜表面的真菌,对于免疫发育和健康至关重要. 干扰 (dysbiosis) 与疾病有关,这表明了新的治疗点.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 人类健康 人类健康 人类健康
背景情况:
- 人类的真菌生物群,粘膜表面上的真菌群体,越来越多地被认为是从出生到成年期的角色.
- 是免疫系统发育和维持平衡的组成部分.
- 最近的进展显著扩大了我们对真菌生物组的组成和功能的理解.
研究的目的:
- 审查最近关于人体微生物组在不同身体部位的研究进展.
- 探索真菌生物和宿主免疫系统之间的复杂相互作用.
- 讨论真菌生物组失生症在疾病发病和潜在的治疗策略中的影响.
主要方法:
- 关于人类真菌生物组的最新研究的文献综述.
- 分析研究的分析,研究在人体各个部位的真菌生物组合和功能.
- 综合了关于宿主 - 菌群 - 免疫相互作用和疾病关联的发现.
主要成果:
- 人类的真菌生物群殖民于多个粘膜部位,包括胃肠道,呼吸道,泌尿器官和口腔道,以及皮肤和瘤组织.
- 显著的研究工作集中在表征菌群-免疫系统相互作用,特别是在胃肠道内.
- 菌生菌组失生症与各种疾病的进展有关,包括炎症性肠道疾病,酒精性肝脏疾病,全身感染和癌症.
结论:
- 人类的真菌生物组在免疫平衡中发挥着至关重要的作用.
- 菌群生物的失生与许多病理状况有关.
- 向真菌生物组为针对危及生命的疾病的新型治疗干预提供了一个有希望的途径.
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