在儿科CSF样本中检测人类疹病毒6:引起疾病还是偶然的分心?
Huanyu Wang1, Cristina Tomatis-Souverbielle2, Kathy Everhart3
1Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, USA; Department of Pathology, The Ohio State University, Columbus, OH, USA.
Diagnostic microbiology and infectious disease
|August 1, 2023
概括
在脑脊液 (CSF) 中检测人类疹病毒6型 (HHV6) 可能是复杂的. 偶然染色体整合 (iciHHV6) 经常在幼儿中发现,特别是那些被评估为败血症的婴儿,可能不表明活跃的感染.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 分子诊断学 分子诊断
背景情况:
- 人类疹病毒6型 (HHV6) 在脑脊液 (CSF) 中的检测提出了解释挑战.
- HHV6可以表现为急性感染,重新激活或染色体整合 (iciHHV6).
- 区分这些形式对于准确的诊断和患者管理至关重要.
研究的目的:
- 确定小儿CSF样本中的HHV6和iciHHV6的流行率.
- 为了比较患有和没有ciHHV6.6的患者的临床和实验室特征.
- 为了澄清在脑脊髓炎中检测HHV6的意义,特别是在婴儿中.
主要方法:
- 对儿童脑脊液样本进行HHV6DNA的回顾性分析.
- 临床数据审查,包括患者人口统计,症状和实验室发现.
- 在iciHHV6阳性和阴性组之间,在CSF和全血中的病毒载荷的比较.
主要成果:
- 在CSF中,HHV6和iciHHV6的总流行率分别为2.4%和0.85%.
- 患有iciHHV6的儿童年轻,发烧不太可能;65.2%的婴儿被评估为败血症.
- 患有iciHHV6的患者的病毒载量较高,偶发检测很常见 (91.3%对33.3%).
结论:
- 在CSF中分子检测到HHV6并不总是意味着活跃的感染.
- iciHHV6是一个重要的发现,特别是在出现败血症症状的幼儿中.
- 区分iciHHV6和活跃的HHV6感染对于适当的临床决策至关重要.
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