在左心室辅助装置植入受体中使用冷等离子体和驱动线感染
Volker Lauenroth1, Armin Zittermann, Stefan Lucke
1From the Clinic for Thoracic and Cardiovascular Surgery, Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Ruhr University Bochum, Germany.
概括
阿贡冷血 (ACP) 在左心室辅助器件 (LVAD) 患者中显著减少驱动线感染 (DLI),长达六个月. 这种预防措施改善了感染的免费性,而非非ACP使用.
科学领域:
- 医疗器械 医疗器械
- 预防传染病 预防传染病
- 血医学是一种血医学.
背景情况:
- 左心室辅助装置 (LVAD) 植入对于末期心力衰竭至关重要.
- 驱动线感染 (DLI) 仍然是一个显著的并发症,影响患者的治疗结果.
- 需要新的策略来减轻LVAD接受者的DLI风险.
研究的目的:
- 评估冷血 (ACP) 应用在预防DLI后LVAD植入后的疗效.
- 为了比较接受预防性ACP和对照组患者之间的结果.
主要方法:
- 潜在的,开放标签的,二对二因子临床试验.
- 80名患者随机分为控制组 (没有ACP) 或ACP (30天预防性使用) 组.
- 随访1年,评估DLI和设备上的存活率.
主要成果:
- 预防性ACP显著改善了30天的DLI自由 (100%对85%,p=0.012) 和6个月的自由 (92%对69%,p=0.007).
- 在30天的设备生存时间没有显著差异 (p=0.32).
- 在对照组的一年后,对设备的存活率较低的趋势 (74%对90%,p=0.09).
结论:
- 预防性ACP应用在应用期间和植入后长达6个月的LVAD患者的DLI显著降低.
- 作为一个有效的DLI预防策略,ACP显示出潜力.
- 对长期生存益处的进一步调查是有必要的.
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