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Updated: Jul 20, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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5 - 替代皮里丁-2,4-二碳酸盐衍生物具有选择性抑制人类Jumonji-C域含蛋白5的潜力

Lennart Brewitz1, Yu Nakashima1, Sonia K Piasecka2

  • 1Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, OX1 3TA Oxford, U.K.

Journal of medicinal chemistry
|August 1, 2023
PubMed
概括

研究人员开发了新的5-aminoalkyl-substituted 2,4-PDCA衍生物,可以选择性地抑制Jumonji-C域含蛋白5 (JMJD5). 这些强大的JMJD5抑制剂为研究其在发育,昼夜节律和癌症中的作用提供了宝贵的工具.

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