确定最佳正极呼气压的方法:范围审查的协议
Stefan Edginton1, Natalia Kruger1, Henry Tom Stelfox1,2
1Critical Care Medicine, University of Calgary Cumming School of Medicine, Calgary, Alberta, Canada.
BMJ open
|August 1, 2023
概括
在机械通风过程中确定最佳的正极呼气压 (PEEP) 缺乏标准化的方法. 本范围审查确定了当前的PEEP定位技术,患者群体和结果,以突出研究差距并为未来的元分析提供信息.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统生理学 呼吸系统生理学
- 证据综合 证据综合
背景情况:
- 定位的正极呼气压 (PEEP) 在机械通风中至关重要.
- 目前用于确定最佳PEEP的方法在临床实践和研究中存在很大差异.
- 需要对现有的PEEP定位策略有系统的了解.
研究的目的:
- 系统地识别和分类用于确定最佳PEEP的所有方法.
- 绘制与每个PEEP确定方法相关的患者群体,测量结果和研究设计的地图.
- 确定目前关于最佳PEEP的文献中的空白,以及未来元分析的潜在领域.
主要方法:
- 将采用一个全面的范围审查方法.
- 使用PCC框架将制定一个强大的搜索策略,并在五个主要数据库 (MEDLINE,EMBASE,CENTRAL,Web of Science,Scopus) 执行.
- 独立的查和多个研究人员的数据提取将确保包括的研究的严格分析,根据PEEP方法,研究设计,患者群体和结果对其进行分类.
主要成果:
- 该审查将详细描述各种PEEP定位方法.
- 将阐明每个已识别的方法的优点和局限性.
- 将绘制最佳PEEP确定研究格局,突出应用和研究设计的差异.
结论:
- 这次范围审查将综合有关最佳PEEP决定的当前知识状况.
- 它旨在确定文献中的关键差距,指导未来的研究和证据综合.
- 这些发现将为临床实践指南提供信息,并可能完善机械通风策略.
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